Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum.

ABSTRACT:

Background

The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards treatment failure. Monitoring the prevalence of mutations associated with artemisinin resistance in African populations is necessary to stop resistance in its tracks. Mutations in Plasmodium falciparum genes pfk13, pfcoronin and pfatpase6 have been linked with ART partial resistance.

Methods

Findings from published research articles on the prevalence of pfk13, pfcoronin and pf

SUBMITTER: Owoloye A 

PROVIDER: S-EPMC8638531 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature