Zeb2 regulates the balance between retinal interneurons and Muller glia by inhibition of BMP-Smad signaling.

ABSTRACT: The interplay between signaling molecules and transcription factors during retinal development is key to controlling the correct number of retinal cell types. Zeb2 (Sip1) is a zinc-finger multidomain transcription factor that plays multiple roles in central and peripheral nervous system development. Haploinsufficiency of ZEB2 causes Mowat-Wilson syndrome, a congenital disease characterized by intellectual disability, epilepsy and Hirschsprung disease. In the developing retina, Zeb2 is required for generation of horizontal cells and the correct number of interneurons; however, its potential function in controlling gliogenic versus neurogenic decisions remains unresolved. Here we present cellular and molecular evidence of the inhibition of Müller glia cell fate by Zeb2 in late stages of reti

SUBMITTER: Menuchin-Lasowski Y 

PROVIDER: S-EPMC8638546 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature