Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances.

ABSTRACT:

Purpose

Calibration of hyperpolarized ¹³ C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires ¹³ C-enriched external phantoms. This study investigated the feasibility of using either ²³ Na-MRI or ¹ H-MRI to calibrate the ¹³ C excitation.

Methods

Commercial ¹³ C-coils were used to estimate the transmit gain and center frequency for ¹³ C and ²³ Na resonances. Simulations of the transmit B₁ profile of a Helmholtz loop were performed. Noise correlation was measured for both nuclei. A retrospective analysis of human data assessing the use of the ¹ H resonance to predict [1-¹³ C]pyruvate center frequency was al

SUBMITTER: Grist JT 

PROVIDER: S-EPMC8638662 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature