Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE).

ABSTRACT:

Aim

High-altitude pulmonary oedema (HAPE) is a non-cardiogenic pulmonary oedema that can occur during rapid ascent to a high-altitude environment. Classically, HAPE has been described as a condition resulting from a combination of pulmonary vasoconstriction and hypertension. Inflammation has been described as important in HAPE, although as a side effect of pulmonary oedema rather than as a causative factor. In this study, we aim to understand the role of hypoxic response in myeloid cells and its involvement in pathogenesis of HAPE.

Methods

We have generated a conditional deletion in mice of the von Hippel-Lindau factor (VHL) in myeloid cells to determine the effect of a deregulated hypoxic response in pulmonary oedema.

Results

The deletion of VHL in pulmonary myeloid

SUBMITTER: Gojkovic M 

PROVIDER: S-EPMC8638671 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature