Catalytic asymmetric addition of an amine N-H bond across internal alkenes.

ABSTRACT: Hydroamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, yet challenging, organic transformation that creates an alkylamine from two abundant chemical feedstocks, alkenes and amines, with full atom economy^1-3. The reaction is particularly important because amines, especially chiral amines, are prevalent substructures in a wide range of natural products and drugs. Although extensive efforts have been dedicated to developing catalysts for hydroamination, the vast majority of alkenes that undergo intermolecular hydroamination have been limited to conjugated, strained, or terminal alkenes^2-4; only a few examples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes^5-7, including

SUBMITTER: Xi Y 

PROVIDER: S-EPMC8638802 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature