Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.

ABSTRACT:

Rationale

The initial hypertrophy response to cardiac pressure overload is considered compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role for recruited macrophages in determining the transition from compensated to decompensated hypertrophy has been established. However, whether cardiac resident immune cells influence the early phase of hypertrophy development has not been established.

Objective

To assess the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload induced by transverse aortic constriction (TAC).

Methods and results

We performed cytometry by time-of-flight to determine the identity and abundance of immune cells in the heart at 1 and 4 weeks after TAC. We observed a substanti

SUBMITTER: Revelo XS 

PROVIDER: S-EPMC8638822 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature