What Can Genetic Relatedness Tell Us About Risk Factors for Tuberculosis Transmission?

ABSTRACT:

Background

To stop tuberculosis (TB), the leading infectious cause of death globally, we need to better understand transmission risk factors. Although many studies have identified associations between individual-level covariates and pathogen genetic relatedness, few have identified characteristics of transmission pairs or explored how closely covariates associated with genetic relatedness mirror those associated with transmission.

Methods

We simulated a TB-like outbreak with pathogen genetic data and estimated odds ratios (ORs) to correlate each covariate and genetic relatedness. We used a naive Bayes approach to modify the genetic links and nonlinks to resemble the true links and nonlinks more closely and estimated modified ORs with this approach. We compared these two sets

SUBMITTER: Leavitt SV 

PROVIDER: S-EPMC8638913 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature