A specific structure and high richness characterize intestinal microbiota of HIV-exposed seronegative individuals.

ABSTRACT: Intestinal microbiota facilitates food breakdown for energy metabolism and influences the immune response, maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. However, it is unclear whether microbiota dysbiosis is the cause or the effect of immune alterations and disease progression or if it could modulate the risk of acquiring the HIV infection. We characterize the intestinal microbiota and determine its association with immune regulation in HIV-exposed seronegative individuals (HESN), HIV-infected progressors (HIV+), and healthy control (HC) subjects. For this, feces and blood were collected. The microbiota composition of HESN showed a significantly high

SUBMITTER: Lopera TJ 

PROVIDER: S-EPMC8638974 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature