Serial measurement of cytokines strongly predict COVID-19 outcome.

ABSTRACT:

Purpose

Cytokines are major mediators of COVID-19 pathogenesis and several of them are already being regarded as predictive markers for the clinical course and outcome of COVID-19 cases. A major pitfall of many COVID-19 cytokine studies is the lack of a benchmark sampling timing. Since cytokines and their relative change during an infectious disease course is quite dynamic, we evaluated the predictive value of serially measured cytokines for COVID-19 cases.

Methods

In this single-center, prospective study, a broad spectrum of cytokines were determined by multiplex ELISA assay in samples collected at admission and at the third day of hospitalization. Appropriateness of cytokine levels in predicting mortality were assessed by receiver-operating characteristic (ROC) analyses fo

SUBMITTER: Ozger HS 

PROVIDER: S-EPMC8639000 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature