Polypharmacy-associated risk of hospitalisation among people ageing with and without HIV: an observational study.

ABSTRACT:

Background

Polypharmacy, defined as use of five or more medications concurrently, is associated with adverse health outcomes and people ageing with HIV might be at greater risk than similar uninfected individuals. We aimed to determine whether known pairwise drug interactions (KPDIs) were associated with risk of admission to hospital (hereafter referred to as hospitalisation) and medication count among people ageing with and without HIV after accounting for physiological frailty.

Methods

In this observational study, we collected individual-level data for participants of the Veterans Aging Cohort Study (VACS) with HIV on antiretroviral therapy (ART) and with supressed HIV-1 RNA and people without HIV who were receiving at least one prescription medication, based on active med

SUBMITTER: Justice AC 

PROVIDER: S-EPMC8639138 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature