Identification of metabolomic profile related to adult Fontan pathophysiology.

ABSTRACT:

Background

Metabolic disorders are important pathophysiologies that can cause multiple organ dysfunction and worsen prognosis in Fontan patients. This study aimed to comprehensively evaluate the metabolomic profile of adult Fontan patients and characterize its pathophysiology in relation to 2 control groups.

Methods and results

We performed metabolomic analysis of 31 plasma samples using capillary electrophoresis time-of-flight mass spectrometry. This observational cross-sectional study compared plasma metabolites of 14 heterogeneous adult Fontan patients with those of control groups, including 9 patients with congenital heart disease after biventricular repair and 8 normal healthy controls. Fontan patients exhibited significant differences in intermediate metabolite concent

SUBMITTER: Motoki N 

PROVIDER: S-EPMC8639334 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature