Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure.

ABSTRACT: The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that controls axonal trafficking and maintains a high density of voltage-gated ion channels linked by scaffold proteins to the AIS cytoskeleton. However, our knowledge of the mechanisms and proteins involved in AIS cytoskeleton regulation to maintain or modulate AIS structure is limited. In this context, formins play a significant role in the modulation of actin and microtubules. We show that pharmacological inhibition of formins modifies AIS actin and microtubule characteristics in cultured hippocampal neurons, reducing F-actin density and decreasing micr

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8639558 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature