The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia.

ABSTRACT: Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well characterized niches to produce molecular and cellular mechanisms that interfere with differentiation, migration, survival, and proliferation in this microenvironment. The acute myeloid leukemia (AML), the most common and severe hematological neoplasm in adults, arises and develop in the BM. The osteoblastic, vascular, and reticular niches provide surface co-receptors, soluble factors, cytokines, and chemokines that mediate important functions on hematopoietic cells and leukemic blasts. There are some evidences of how AML modify the architecture and function of these three BM niches, but it has been still unclea

SUBMITTER: Pimenta DB 

PROVIDER: S-EPMC8639599 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature