Prenatal maternal pesticide exposure in relation to sleep health of offspring during adolescence.

ABSTRACT:

Study objectives

The neurobiological processes involved in establishing sleep regulation are vulnerable to environmental exposures as early as seven weeks of gestation. Studies have linked in utero pesticide exposure to childhood sleep-disordered breathing. However, the impact of in utero pesticide exposure on the sleep health of adolescents remains unexplored.

Materials and methods

Data from 137 mother-adolescent pairs from a Mexico City cohort were analyzed. We used maternal urinary 3-phenoxybenzoic acid (3-PBA, pyrethroid metabolite) and 3, 5, 6-trichloro-2-pyridinol (TCPy, chlorpyrifos metabolite) from trimester three to estimate in utero pesticide exposure. Among adolescents, we obtained repeated measures of objectively assessed sleep duration, midpoint, and fragmentati

SUBMITTER: Zamora AN 

PROVIDER: S-EPMC8639673 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature