Profiling the chemical nature of anti-oxytotic/ferroptotic compounds with phenotypic screening.

ABSTRACT: Because old age is the greatest risk factor for Alzheimer's disease (AD), it is critical to target the pathological events that link aging to AD in order to develop an efficient treatment that acts upon the primary causes of the disease. One such event might be the activation of oxytosis/ferroptosis, a unique cell death mechanism characterized by mitochondrial dysfunction and lethal lipid peroxidation. Here, a comprehensive library of >900 natural compounds was screened for protection against oxytosis/ferroptosis in nerve cells with the goal of better understanding the chemical nature of inhibitors of oxytosis/ferroptosis. Although the compounds tested spanned structurally diverse chemical classes from animal, microbial, plant and synthetic origins, a small set of very potent anti-oxytotic

SUBMITTER: Soriano-Castell D 

PROVIDER: S-EPMC8639737 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature