The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss.

ABSTRACT:

New findings

What is the central question of this study? Is the oestrous cycle affected during disuse atrophies and, if so, how are oestrous cycle changes related to musculoskeletal outcomes? What is the main finding and its importance? Rodent oestrous cycles were altered during disuse atrophy, which was correlated with musculoskeletal outcomes. However, the oestrous cycle did not appear to be changed by Lewis lung carcinoma, which resulted in no differences in muscle size in comparison to healthy control animals. These findings suggest a relationship between the oestrous cycle and muscle size during atrophic pathologies.

Abstract

Recent efforts have focused on improving our understanding of female muscle physiology during exposure to muscle atrophic stimuli. A key feature o

SUBMITTER: Rosa-Caldwell ME 

PROVIDER: S-EPMC8639792 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature