Mechanism for the activation of the anaplastic lymphoma kinase receptor.

ABSTRACT: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system^1,2. The ALK gene is a hotspot for chromosomal translocation events that result in several fusion proteins that cause a variety of human malignancies³. Somatic and germline gain-of-function mutations in ALK were identified in paediatric neuroblastoma^4-7. ALK is composed of an extracellular region (ECR), a single transmembrane helix and an intracellular tyrosine kinase domain^8,9. ALK is activated by the binding of ALKAL1 and ALKAL2 ligands^10-14 to its ECR, but the lack of structural information for the ALK-ECR or for ALKAL ligands has limited our understanding of ALK activation. Here we used cryo-electron

SUBMITTER: Reshetnyak AV 

PROVIDER: S-EPMC8639797 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature