A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes.

ABSTRACT: Epidermal photoaging contributes to skin fragility over time and it is a risk factor for skin cancer. Photoaging has been associated for a long time with exposure to Ultraviolet-A (UVA) light, the predominant component of the solar ultraviolet radiation. While the cellular mechanisms underlying UVA-induced photoaging in the dermis have been well characterized, UVA's action on the epidermis remains elusive. Here, proteomic analysis was conducted to derive the cellular responses induced by an environmentally relevant dose of UVA in primary human keratinocytes. We also investigated the effects of UVA on non-transformed immortalized keratinocytes (HaCaT cells), bearing potentially oncogenic mutations. We showed that UVA induces proteome remodeling and senescence in primary keratinocytes, elici

SUBMITTER: Valerio HP 

PROVIDER: S-EPMC8639817 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature