Efficient production of valinomycin by the soil bacterium, Streptomyces sp. ZJUT-IFE-354.

ABSTRACT: A novel strain with antifungal activity against Sclerotinia sclerotiorum was isolated from soil, and identified as Streptomyces sp. ZJUT-IFE-354 using morphological and 16S rDNA sequence analysis. The bioactive metabolite produced by strain ZJUT-IFE-354 was identified and characterized as valinomycin by spectroscopic and chemical methods. The yield of valinomycin was 191.26 mg/L from the culture of Streptomyces sp. ZJUT-IFE-354, which was the highest yield to our knowledge. The in vitro antifungal activity of valinomycin against S. sclerotiorum was investigated as 0.056 ± 0.012 (EC₅₀) and 0.121 ± 0.023 μg/mL (EC₉₅), respectively, which was approximately 10.696- and 30.960-fold more active than that of carbendazim. The results from scanning

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8639877 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature