Predictive Performance of Placental Protein 13 for Screening Preeclampsia in the First Trimester: A Systematic Review and Meta-Analysis.

ABSTRACT: Preeclampsia is a pregnancy-specific syndrome that affects maternal and neonatal mortality. Several serum biomarkers can be used to predict preeclampsia. Among these proteins, placental protein 13 (PP13) has received progressively more interest in recent studies. The decrease in PP13 expression is one of the earliest signs for the development of preeclampsia and has shown its predictive performance for preeclampsia. In this meta-analysis, we collected 17 observational studies with 40,474 pregnant women. The overall sensitivity of PP13 to predict preeclampsia was 0.62 [95% confidence interval (CI) = 0.49-0.74], the specificity was 0.84 (95%CI = 0.81-0.86), and the diagnostic odds ratio was nine (95%CI = 5-15). The area under the curve for summary receiver operating characteristic was 0.84.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8640131 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature