A review of computational tools for generating metagenome-assembled genomes from metagenomic sequencing data.

ABSTRACT: Metagenomic sequencing provides a culture-independent avenue to investigate the complex microbial communities by constructing metagenome-assembled genomes (MAGs). A MAG represents a microbial genome by a group of sequences from genome assembly with similar characteristics. It enables us to identify novel species and understand their potential functions in a dynamic ecosystem. Many computational tools have been developed to construct and annotate MAGs from metagenomic sequencing, however, there is a prominent gap to comprehensively introduce their background and practical performance. In this paper, we have thoroughly investigated the computational tools designed for both upstream and downstream analyses, including metagenome assembly, metagenome binning, gene prediction, functional annotat

SUBMITTER: Yang C 

PROVIDER: S-EPMC8640167 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature