A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.

ABSTRACT: The parotid, submandibular, and sublingual glands represent a trio of oral secretory glands whose primary function is to produce saliva, facilitate digestion of food, provide protection against microbes, and maintain oral health. While recent studies have begun to shed light on the global gene expression patterns and profiles of salivary glands, particularly those of mice, relatively little is known about the location and identity of transcriptional control elements. Here we have established the epigenomic landscape of the mouse submandibular salivary gland (SMG) by performing chromatin immunoprecipitation sequencing experiments for 4 key histone marks. Our analysis of the comprehensive SMG data sets and comparisons with those from other adult organs have identified critical enhancers and

SUBMITTER: Gluck C 

PROVIDER: S-EPMC8640340 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature