Ontology highlight
ABSTRACT:
SUBMITTER: Le SC
PROVIDER: S-EPMC8640346 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Le Son C SC Liang Pengfei P Lowry Augustus J AJ Yang Huanghe H
Frontiers in physiology 20211119
The transmembrane protein 16 (TMEM16) family consists of Ca<sup>2+</sup>-activated ion channels and Ca<sup>2+</sup>-activated phospholipid scramblases (CaPLSases) that passively flip-flop phospholipids between the two leaflets of the membrane bilayer. Owing to their diverse functions, TMEM16 proteins have been implicated in various human diseases, including asthma, cancer, bleeding disorders, muscular dystrophy, arthritis, epilepsy, dystonia, ataxia, and viral infection. To understand TMEM16 pro ...[more]