Neuronal network mechanisms associated with depressive symptom improvement following electroconvulsive therapy.

ABSTRACT:

Background

Electroconvulsive therapy (ECT) is the most effective antidepressant treatment for severe depression. Although recent structural magnetic resonance imaging (MRI) studies have consistently reported ECT-induced hippocampal volume increases, most studies did not find the association of the hippocampal volume changes with clinical improvement. To understand the underlying mechanisms of ECT action, we aimed to identify the longitudinal effects of ECT on hippocampal functional connectivity (FC) and their associations with clinical improvement.

Methods

Resting-state functional MRI was acquired before and after bilateral ECT in 27 depressed individuals. A priori hippocampal seed-based FC analysis and a data-driven multivoxel pattern analysis (MVPA) were conducted to inves

SUBMITTER: Takamiya A 

PROVIDER: S-EPMC8640363 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature