Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury.

ABSTRACT:

Aim

Hyperleptinemia potentiates the effects of many atherogenic factors, such as inflammation, platelet aggregation, migration, hypertrophy, proliferation of vascular smooth muscle cells, and endothelial cell dysfunction. The present study analysed the effects of long-term hyperleptinemia in an in vivo myocardial ischemia-reperfusion model to demonstrate whether the in vivo deleterious effect also affects cardiac structure and function.

Main methods

Rats were subcutaneously administered leptin for 8 days to estimate the involvement of the JAK/STAT pathway. Data from 58 male Wistar rats were included in the final analysis. Myocardial infarction (MI) was modelled by the 30-minute ligation of the main left coronary artery followed by 120-minute reperfusion. Hemodynamic measurem

SUBMITTER: Polyakova EA 

PROVIDER: S-EPMC8640453 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature