The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function.

ABSTRACT: The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin-related protein (RdCVF2L), an enzyme that regulates the phosphorylation of TAU. To investigate the link between NXNL2 and tauopathies, we studied the Nxnl2 knockout mouse (Nxnl2^-/-). We established the expression pattern of the Nxnl2 gene in the brain using a Nxnl2 reporter mouse line, and characterized the behavior of the Nxnl2^-/- mouse at 2 months of age. Additionally, long term potentiation and metabolomic from hippocampal specimens were collected at 2 months of age. We studied TAU oligomerization, phosphorylation and aggregation in Nxnl2^-/- brain at 18 months of age. Finally,

SUBMITTER: Jaillard C 

PROVIDER: S-EPMC8640531 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature