Conjugating Micropatches to Living Cells Through Membrane Intercalation.

ABSTRACT: Existing clinical cell therapies, which rely on the use of biological functionalities of living cells, can be further enhanced by conjugating functional particles to the cells to form cell-particle complexes. Disk-shaped microparticles produced by the top-down microfabrication approach possess unique advantages for this application. However, none of the current mechanisms for conjugating the microfabricated microparticles to the cells are principally applicable to all types of cells with therapeutic potentials. On the other hand, membrane intercalation is a well-established mechanism for attaching fluorescent molecules to living cells or for immobilizing cells on a solid surface. This paper reports a study on conjugating disk-shaped microparticles, referred to as micropatches, to living ce

SUBMITTER: Miao Y 

PROVIDER: S-EPMC8640532 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature