Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of GPR56/ADGRG1 in health and disease.

ABSTRACT: GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

SUBMITTER: Singh AK

PROVIDER: S-EPMC8640549 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

Project description: Not available

| S-EPMC5839751 | biostudies-literature

GPR56/ADGRG1 is associated with response to antidepressant treatment.

Project description: Not available

| S-EPMC7118175 | biostudies-literature

ADGRG1/GPR56 knockdown in cord blood CD34+ cells

Project description:ADGRG1/GPR56 was knocked down by two different shRNAs in cord blood CD34+ cells via lentiviral transduction. GFP was used as marker indicating successful transduction.

2022-02-06 | GSE150175 | GEO

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.

Project description: Not available

| S-EPMC5036532 | biostudies-literature

GPR56/ADGRG1 is associated with response to antidepressant treatment

Project description:It remains unclear why many patients with depression do not respond to antidepressant treatment. In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N=424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in the blood. In a small group of subjects we also show that GPR56 is also downregulated in the PFC of individuals with depression that died by suicide. In mice, we show that chronic stress induced Gpr56 downregulation in the blood and prefrontal cortex (PFC), which is accompanied by depression-like behaviour, and can be reversed by antidepressant treatment. Gpr56 knockdown in mouse PFC was is associated with depressive-like behaviors, executive dysfunction and poor response to antidepressant treatment. GPR56 peptide agonists had antidepressant-like effects and up-regulated AKT/GSK3/EIF4 pathways. Our findings uncover a potential role of GPR56 in antidepressant response.

2020-03-31 | GSE146446 | GEO

GPR56/ADGRG1 inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma

Project description:A mesenchymal transition occurs both during natural evolution of glioblastoma (GBM) and in response to therapy. However, the molecular mechanisms underlying mesenchymal differentiation are not well understood. We have found that the adhesion G protein-coupled receptor, GPR56/ADGRG1, inhibits mesenchymal differentiation and radioresistance in glioblastoma stem-like initiating cells (GICs). Here, we have performed microarray analysis of control- versus GPR56 knockdown-GICs to characterize gene expression changes upon GPR56 knockdown and identify a gene expression signature associated to GPR56.

2017-10-01 | GSE94765 | GEO

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.

Project description: Not available

| S-EPMC7668045 | biostudies-literature

Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.

Project description: Not available

| S-EPMC8645723 | biostudies-literature

GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer

Project description: Not available

| EMPIAR-11433 | biostudies-other

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region.

Project description: Not available