Urinary 8-hydroxy-2'-deoxyguanosine levels and small-for-gestational age infants: a prospective cohort study from the Japan Environment and Children's Study.

ABSTRACT:

Objectives

To evaluate the association between the urinary 8-hydroxy-2'-deoxyguanosine (U8-OHdG) levels and the incidence of small-for-gestational age (SGA) infants and to assess the utility of U8-OHdG as a biomarker to predict the incidence of SGA infants.

Design

Prospective cohort study.

Setting

The Japan Environment and Children's Study.

Participants

Data of participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study, between 2011 and 2014 were analysed; 104 062 fetal records were analysed. Data of women with singleton pregnancies ≥22 weeks of gestation were analysed.

Primary and secondary outcome measures

U8-OHdG levels were assessed using liquid chromatography-tandem mass spectrometry. Participants were categ

SUBMITTER: Murata T 

PROVIDER: S-EPMC8640663 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature