Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth.

ABSTRACT: Among CD4⁺ T cells, T helper 17 (Th17) cells are particularly susceptible to HIV-1 infection and are depleted from mucosal sites, which causes damage to the gut barrier, resulting in a microbial translocation-induced systemic inflammation, a hallmark of disease progression. Furthermore, a proportion of latently infected Th17 cells persist long term in the gastrointestinal lymphatic tract where a low-level HIV-1 transcription is observed. This residual viremia contributes to chronic immune activation. Thus, Th17 cells are key players in HIV pathogenesis and viral persistence. It is, however, unclear why these cells are highly susceptible to HIV-1 infection. Th17 cell differentiation depends on the expression of the master transcriptional regulator RORC2, a retinoic

SUBMITTER: Wiche Salinas TR 

PROVIDER: S-EPMC8640723 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature