CD11b⁺DIP2A⁺LAG3⁺ cells facilitate immune dysfunction in colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, and tumor metastasis is the leading cause of death. Targeting immune inhibitory checkpoint inhibitory pathways has attracted great attention, since the therapeutic efficacy induced by the specific blocking antibodies has been demonstrated even in metastatic CRC patients. However, the clinical outcome is low in many cases, and thus more effective treatments are needed in the clinical settings. A SPARC family member follistatin-like 1 (FSTL1) is known as a key driver of tumor metastasis in various types of cancer. However, the immunological roles of the FSTL1 in the CRC pathogenesis remain to be elucidated. In this study, we investigated the molecular mechanisms underlying the refractory FSTL1⁺ CRC using

SUBMITTER: Kudo-Saito C 

PROVIDER: S-EPMC8640801 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature