Tendon midsubstance trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model.

ABSTRACT:

Background

Chronic degeneration of rotator cuff tendons is a major contributing factor to the unacceptably high prevalence of rotator cuff repair surgery failures. The etiology of chronic rotator cuff degeneration is not well understood, and current therapies are not effective, necessitating preclinical research to fill this knowledge gap. Unfortunately, current large animal models rely on enthesis disruption as a means of model generation, which is not representative of human patients with chronic rotator cuff degeneration prior to full-thickness tears. Following, the goal of this study was to develop and characterize a translational large-animal model of chronic rotator cuff degeneration without enthesis release.

Methods

A midsubstance damage model [i.e., "combed fenestrat

SUBMITTER: Johnson J 

PROVIDER: S-EPMC8640899 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature