Immune-Mediated Diseases Associated With Cancer Risks.

ABSTRACT:

Importance

Immune regulation is important for carcinogenesis; however, the cancer risk profiles associated with immune-mediated diseases need further characterization.

Objective

To assess the prospective association of 48 immune-mediated diseases with the risk of total and individual cancers and the prospective association of organ-specific immune-mediated diseases with the risk of local and extralocal cancers.

Design, setting, and participants

This prospective cohort study used data from the UK Biobank cohort study on adults aged 37 to 73 years who were recruited at 22 assessment centers throughout the UK between January 1, 2006, and December 31, 2010, with follow-up through February 28, 2019.

Exposures

Immune-mediated diseases.

Main outcomes and measures</

SUBMITTER: He MM 

PROVIDER: S-EPMC8640951 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature