Sensitivity Enhancement by Progressive Saturation of the Proton Reservoir: A Solid-State NMR Analogue of Chemical Exchange Saturation Transfer.

ABSTRACT: Chemical exchange saturation transfer (CEST) enhances solution-state NMR signals of labile and otherwise invisible chemical sites, by indirectly detecting their signatures as a highly magnified saturation of an abundant resonance─for instance, the ¹H resonance of water. Stimulated by this sensitivity magnification, this study presents PROgressive Saturation of the Proton Reservoir (PROSPR), a method for enhancing the NMR sensitivity of dilute heteronuclei in static solids. PROSPR aims at using these heteronuclei to progressively deplete the abundant ¹H polarization found in most organic and several inorganic solids, and implements this ¹H signal depletion in a manner that reflects the spectral intensities of the heteronuclei as a function of their chemical

SUBMITTER: Jaroszewicz MJ 

PROVIDER: S-EPMC8640991 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature