Interaction of Klebsiella pneumoniae with tissue macrophages in a mouse infection model and ex-vivo pig organ perfusions: an exploratory investigation.

ABSTRACT:

Background

Hypervirulent Klebsiella pneumoniae (hvKp) strains of capsule type K1 and K2 cause invasive infections associated with hepatic abscesses, which can be difficult to treat and are frequently associated with relapsing infections. Other K pneumoniae strains (non-hvKp), including lineages that have acquired carbapenem resistance, do not manifest this pathology. In this work we aimed to test the hypothesis that within-macrophage replication is a key mechanism underpinning abscess formation in hvKp infections.

Methods

In this exploratory investigation, to study the pathophysiology of abscess formation, mice were intravenously infected with 10⁶ colony forming units (CFU) of either hvKp isolates (six strains) or non-hv

SUBMITTER: Wanford JJ 

PROVIDER: S-EPMC8641047 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature