Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies.

ABSTRACT: Perinatal brain injury can lead to significant neurological and cognitive deficits and currently no therapies can regenerate the damaged brain. Neural stem cells (NSCs) have the potential to engraft and regenerate damaged brain tissue. The aim of this systematic review was to evaluate the preclinical literature to determine whether NSC administration is more effective than controls in decreasing perinatal brain injury. Controlled interventional studies of NSC therapy using animal models of perinatal brain injury were identified using MEDLINE and Embase. Primary outcomes were brain infarct size, motor, and cognitive function. Data for meta-analysis were synthesized and expressed as standardized mean difference (SMD) with 95% confidence intervals (CI), using a random effects model. We also r

SUBMITTER: Smith MJ 

PROVIDER: S-EPMC8641092 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature