Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children.

ABSTRACT:

Background

RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kinetics of RTS,S/AS01-induced antibodies was investigated.

Methods

150 participants were randomly selected from the 447 children who participated in the RTS,S/AS01 phase IIb clinical trial in 2007 from Kilifi-Kenya. Cumulatively, the retrospective follow-up period was 93 months with annual plasma samples collection. The levels of anti-CSP IgM, total IgG, IgG1, IgG2, IgG3, and IgG4 antibodies were then determined using an enzyme-linked immunosorbent assay.

Results

RTS,S/AS01 induced high levels of anti-CSP IgG antibodies which exhibite

SUBMITTER: Mugo RM 

PROVIDER: S-EPMC8641151 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature