Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia.

ABSTRACT:

Background

To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the analgesic activity of brimonidine.

Methods

The median effective dose (ED₅₀) and lethal dose (LD₅₀) of intraperitoneally injected brimonidine were determined in hypnotized mice. In addition, the LD₅₀ of intravenously injected brimonidine, and ED₅₀ of intravenously, intramuscularly, and intrarectally injected brimonidine in hypnotized rabbits were determined. Finally, the synergistic anesthetic effect of brimonidine and chloral hydrate was evaluated in rabbits.

Results

Intraperiton

SUBMITTER: Bin C 

PROVIDER: S-EPMC8641169 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature