Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet.

ABSTRACT:

Background

Dietary high fructose (HFr) is a known metabolic disruptor contributing to development of obesity and diabetes in Western societies. Initial molecular changes from exposure to HFr on liver metabolism may be essential to understand the perturbations leading to insulin resistance and abnormalities in lipid and carbohydrate metabolism. We studied vervet monkeys (Clorocebus aethiops sabaeus) fed a HFr (n=5) or chow diet (n=5) for 6 weeks, and obtained clinical measures of liver function, blood insulin, cholesterol and triglycerides. In addition, we performed untargeted global transcriptomics, proteomics, and metabolomics analyses on liver biopsies to determine the molecular impact of a HFr diet on coordinated pathways and networks that differed by diet.

Results

We sho

SUBMITTER: Cox LA 

PROVIDER: S-EPMC8641221 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature