Detraining Slows and Maintenance Training Over 6 Years Halts Parkinsonian Symptoms-Progression.

ABSTRACT: Introduction: There are scant data to demonstrate that the long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose in Parkinson's disease (PD). Methods: After randomization, the Exercise-only (E, n = 19) group completed an initial 3-week-long, 15-session supervised, high-intensity sensorimotor agility exercise program designed to improve the postural stability. The Exercise + Maintenance (E + M, n = 22) group completed the 3-week program and continued the same program three times per week for 6 years. The no exercise and no maintenance control (C, n = 26) group continued habitual living. In each patient, 11 outcomes were measured before and after the 3-week initial exercise program and then,

SUBMITTER: Hortobagyi T 

PROVIDER: S-EPMC8641297 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature