Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.

ABSTRACT:

Background and aims

Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile and pancreatic secretions. More precisely, organoids have been derived from ductal tissue located outside (extrahepatic bile ducts; EHBDs) or inside the liver (intrahepatic bile ducts; IHBDs). These organoids share many characteristics, including expression of cholangiocyte markers such as keratin (KRT) 19. However, the relationship between these organoids and their tissues of origin, and to each other, is largely unknown.

Approach and results

Organoids were derived from human gallbladder, common bile duct, pancreatic duct, and IHBDs using culture conditions

SUBMITTER: Rimland CA 

PROVIDER: S-EPMC8641381 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature