Circulating platelet count and glycans.

ABSTRACT:

Purpose of the review

This review highlights recent advancements in understanding the regulation of platelet numbers, focusing on mechanisms by which carbohydrates (glycans) link platelet removal with platelet production in the bone marrow in health and disease.

Recent findings

This review is focused on the role of carbohydrates, specifically sialic acid moieties, as a central mediator of platelet clearance. We discuss recently identified novel mechanisms of carbohydrate-mediated platelet removal and carbohydrate-binding receptors that mediate platelet removal.

Summary

The platelet production rate by megakaryocytes and removal kinetics controls the circulating platelet count. Alterations in either process can lead to thrombocytopenia (low platelet count) or thrombocyt

SUBMITTER: Rivadeneyra L 

PROVIDER: S-EPMC8641398 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature