Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is caused by a novel virus that is responsible for the largest pandemic in recent times. Although numerous studies have explored methods to cope with COVID-19 and targeted drugs and vaccines have been developed, the spread of disease remains rapid due to the high infectivity and mutation capability of SARS-CoV-2, the causative virus of COVID-19. Therefore, there is an urgent necessity to seek more efficient treatments and approaches to combat the disease.

Methods

In this study, molecular docking was used to predict the binding of different lipopeptides, which exhibit significant biological functions, to the RNA-dependent RNA polymerase (also known as nsp12) of SARS-CoV-2, the central component of coronaviral replication and tran

SUBMITTER: Xia B 

PROVIDER: S-EPMC8641408 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature