Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women.

ABSTRACT:

Introduction

Uterine fibroids (UFs) are benign tumors which are derived from the smooth muscle cells of the uterus. Recent studies have demonstrated that the development of UFs can be particularly related to vitamin D and its receptor. Vitamin D comprises a group of fat-soluble steroid compounds which exert powerful, pleiotropic effects all over the human body. These actions are mediated by a specific type of receptor - vitamin D receptor (VDR). Recent findings have focused on the possible role of VDR genetic variations in the development of several types of diseases, e.g. autoimmune system diseases, various cancers and infections.

Material and methods

The aim of the study was to evaluate the association between rs731236, rs1544410, and rs2228570 polymorphisms in the VDR (vi

SUBMITTER: Ciebiera M 

PROVIDER: S-EPMC8641505 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature