Anxiety and Cognition in Cre- Collagen Type II Sirt1 K/O Male Mice.

ABSTRACT:

Introduction

Using transgenic collagen type II-specific Sirt1 knockout (CKO) mice we studied the role of Sirt1 in nutritional induced catch up growth (CUG) and we found that these mice have a less organized growth plate and reduced efficiency of CUG. In addition, we noted that they weigh more than control (CTL) mice. Studying the reason for the increased weigh, we found differences in activity and brain function.

Methods

Several tests for behavior and activity were used: open field; elevated plus maze, Morris water maze, and home cage running wheels. The level of Glu- osteocalcin, known to connect bone and brain function, was measured by Elisa; brain Sirt1 was analyzed by western blot.

Results

We found that CKO mice had increased anxiety, with less spatial memory, lea

SUBMITTER: Shtaif B 

PROVIDER: S-EPMC8641514 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature