Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development.

ABSTRACT: The current Coronavirus Disease 2019 (COVID-19) pandemic is causing great alarm around the world. The pathogen for COVID-19 - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - is the seventh known coronavirus to cause pneumonia in humans. While much remains unknown about SARS-CoV-2, physicians and researchers have begun to publish relevant findings, and much evidence is available on coronaviruses previously circulating in human and animal populations. In this review, we situate COVID-19 in its context as a transboundary viral disease, and provide a comprehensive discussion focused on the discovery, spread, virology, pathogenesis, and clinical features of this disease, its causative coronaviral pathogen, and approaches to combating the disease through immunotherapies and other

SUBMITTER: Ezzikouri S 

PROVIDER: S-EPMC8641599 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature