Population Genomics of Mycobacterium abscessus from U.S. Cystic Fibrosis Care Centers.

ABSTRACT: Rationale: Mycobacterium abscessus is a significant threat to individuals with cystic fibrosis (CF) because of innate drug resistance and potential transmission between patients. Recent studies described global dominant circulating clones of M. abscessus, but detailed genomic surveys have not yet been described for the United States. Objectives: We examined the genetic diversity of respiratory M. abscessus isolates from U.S. patients with CF and evaluated the potential for transmission events within CF Care Centers. Methods: Whole-genome sequencing was performed on 558 M. abscessus isolates from 266 patients with CF attending 48 CF Care Centers in 28 U.S. states as part of a nationwide surveillance program. U.S. isolates were also compared w

SUBMITTER: Davidson RM 

PROVIDER: S-EPMC8641822 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature