Defining Resilience to Smoking-related Lung Disease: A Modified Delphi Approach from SPIROMICS.

ABSTRACT: Rationale: Diagnosis of chronic obstructive pulmonary disease (COPD) relies on abnormal spirometry. However, spirometry may underestimate the effects of smoking, missing smokers with respiratory disease who have minimal or no airflow obstruction. Objectives: To develop a multidimensional definition of a lung-related "resilient smoker" that is useful in research studies and then identify a resilient smoker subgroup in the SPIROMICS (SubPopulations and InteRmediate Outcome Measures In COPD Study) cohort using this definition. Methods: We performed a three-round modified Delphi survey among a panel of COPD experts to identify and reach a consensus on clinical and radiographic domains to be included in a lung-related resilient smoker definition. Consensus on domains of res

SUBMITTER: Oh AL 

PROVIDER: S-EPMC8641833 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature