Systematic analysis of noise reduction properties of coupled and isolated feed-forward loops.

ABSTRACT: Cells can maintain their homeostasis in a noisy environment since their signaling pathways can filter out noise somehow. Several network motifs have been proposed for biological noise filtering and, among these, feed-forward loops have received special attention. Specific feed-forward loops show noise reducing capabilities, but we notice that this feature comes together with a reduced signal transducing performance. In posttranslational signaling pathways feed-forward loops do not function in isolation, rather they are coupled with other motifs to serve a more complex function. Feed-forward loops are often coupled to other feed-forward loops, which could affect their noise-reducing capabilities. Here we systematically study all feed-forward loop motifs and all their pairwise coupled system

SUBMITTER: Chakravarty S 

PROVIDER: S-EPMC8641863 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature