Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals.

ABSTRACT: The brain is a metabolically fragile organ as compromises in fuel availability rapidly degrade cognitive function. Nerve terminals are likely loci of this vulnerability as they do not store sufficient ATP molecules, needing to synthesize them during activity or suffer acute degradation in performance. The ability of on-demand ATP synthesis to satisfy activity-driven ATP hydrolysis will depend additionally on the magnitude of local resting metabolic processes. We show here that synaptic vesicle (SV) pools are a major source of presynaptic basal energy consumption. This basal metabolic processes arises from SV-resident V-ATPases compensating for a hidden resting H⁺ efflux from the SV lumen. We show that this steady-state H⁺ efflux (i) is mediated by vesicular neurotrans

SUBMITTER: Pulido C 

PROVIDER: S-EPMC8641928 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature